Understanding how brain circuits in the hippocampus help with memory and navigation.
Official title: Dissecting the functional organization of local hippocampal circuits underlying spatial representations
Funded at Yale University · NIH-11052561 · Data updated 2026-11-12
This study is looking at how certain brain circuits help us remember things and find our way around, and it hopes to find new ways to help people with memory problems, like those caused by Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 1, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $211,650 |
| NIH project number | 5R00MH129565-03 |
| Project ID | NIH-11052561 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related memory disorders.
✕Less likely to help
Patients with memory issues not related to hippocampal dysfunction or those without a diagnosis of Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the organization and function of hippocampal circuits, which are crucial for forming memories and navigating spaces. By using advanced techniques like electrophysiology, imaging, and optogenetics, the study aims to uncover how these circuits process spatial information and communicate with other brain regions. This understanding could lead to new strategies for addressing memory issues associated with Alzheimer's disease and other neurodegenerative disorders.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve memory function in patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding hippocampal function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Geiller, Tristan — Yale University
- Study coordinator: Geiller, Tristan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.