Understanding how brain circuits for forming social bonds develop
Functional ontogeny of pair bonding neural circuits
This study is looking at how the brain develops the ability to form close relationships during teenage years, using prairie voles as a model, and it hopes to find ways to help people with social challenges, like ADHD or Autism, by understanding how brain chemicals affect bonding.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project ID | NIH-10918104 on NIH RePORTER |
What this research studies
This research investigates the development of brain circuits involved in forming pair bonds, particularly focusing on how these circuits function during adolescence. By studying prairie voles, which are known for their strong pair bonding behaviors, the research aims to uncover how changes in dopamine activity influence social bonding capabilities. The study employs advanced techniques like fiber photometry to measure neural activity and chemogenetics to manipulate it, providing insights into the biological underpinnings of social engagement. This knowledge could lead to improved treatments for individuals with social dysfunctions, such as those with ADHD or Autism Spectrum Disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research include adolescents and adults with social engagement difficulties, such as those diagnosed with ADHD or Autism Spectrum Disorder.
Not a fit: Patients who do not have social engagement issues or related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better therapeutic strategies for individuals struggling with social engagement and related disorders.
How similar studies have performed: Previous research on social bonding in animal models has shown promising results, indicating that this approach could yield valuable insights.
Where this research is happening
Boulder, UNITED STATES
- University of Colorado — Boulder, United States (Active)
Researchers
- Principal investigator: Hiura, Lisa — University of Colorado
- Study coordinator: Hiura, Lisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.