Understanding how brain circuits control self-timed movements
The role of the nigrostriatal circuit in self-timed movements
This study is looking at how certain brain cells that release dopamine help control movements we start on our own, and it's designed for anyone interested in understanding movement disorders better, like Parkinson's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10687831 on NIH RePORTER |
What this research studies
This research investigates the role of dopamine neurons in the nigrostriatal circuit and their influence on self-timed movements, which are movements initiated internally rather than in response to external cues. The study will utilize genetically modified mice to record dopamine neuron activity during these movements, assess the causal relationship between dopamine activity and movement timing, and explore how this activity affects other brain regions. By employing advanced techniques like optogenetics, researchers aim to clarify the mechanisms behind movement disorders and improve our understanding of motor control.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with movement disorders, particularly those experiencing difficulties with self-timed movements.
Not a fit: Patients who do not have movement disorders or those whose conditions are unrelated to the nigrostriatal circuit may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for movement disorders, potentially improving the quality of life for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of dopamine in movement control, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Assad, John — Harvard Medical School
- Study coordinator: Assad, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.