Understanding how brain circuits control fluid flow during sleep and wakefulness
Data Science Core
This study is looking at how brain activity affects the flow of fluid in the brain and how it clears out waste, using advanced imaging techniques in both mice and humans, to help us better understand brain function in different states of awareness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10898600 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which neural circuits regulate cerebrospinal fluid (CSF) flow and solute clearance in both mice and humans. By integrating various types of data, including MRI, two-photon imaging, and EEG, the project aims to develop innovative tools and methods for analyzing complex data sets. The Data Science Core will facilitate collaboration among researchers, ensuring efficient data management and analysis to uncover the relationships between neural activity and fluid dynamics. This comprehensive approach could lead to new insights into brain function during different states of consciousness.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurological conditions that may affect cerebrospinal fluid dynamics.
Not a fit: Patients with conditions unrelated to cerebrospinal fluid flow or those not experiencing neurological issues may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain health and lead to improved treatments for neurological conditions related to CSF flow and clearance.
How similar studies have performed: While the integration of multimodal data in this context is innovative, similar approaches in neuroscience have shown promise in advancing our understanding of brain function.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Kelley, Douglas H — University of Rochester
- Study coordinator: Kelley, Douglas H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.