NIH-funded research R01 grant

Understanding how brain circuits control eating behaviors

Official title: Defining the functional organization of cerebellar output circuits that control feeding behavior

Funded at Scintillon Institute for Photobiology · NIH-10794943 · Data updated 2026-11-12

This study is looking at how certain parts of the brain help control our eating habits and cravings, which could help us understand more about appetite and metabolism.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionScintillon Institute for Photobiology
NIH-funded
Lab location1 site (San Diego, United States)
Project startFebruary 15, 2021
Project endJanuary 31, 2026
Funding year2024
Award (this year)$542,778
NIH project number5R01DK124801-04
Project IDNIH-10794943 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals experiencing eating disorders or obesity who are interested in understanding the neurological factors influencing their behaviors.

Less likely to help

Patients with non-behavioral eating issues, such as those caused by metabolic disorders unrelated to brain function, may not benefit from this research.

What this research studies

This research investigates how specific brain circuits in the cerebellum influence feeding and food-seeking behaviors. By examining the deep cerebellar nuclei (DCN), the study aims to identify distinct pathways that affect food intake and metabolism. The researchers will use advanced techniques like viral tracing and genetic mapping to explore how these circuits interact with other brain regions involved in feeding. This work could provide insights into the neural mechanisms that regulate appetite and eating habits.

Why it matters

Potential benefit: If successful, this research could lead to new treatments for eating disorders and obesity by targeting the brain circuits that control feeding behavior.

How similar studies have gone: Previous research has shown promising results in understanding brain circuits related to feeding behaviors, suggesting that this approach could yield valuable insights.

Where this research is happening

  • Scintillon Institute for Photobiology
    San Diego, United States
    Active

Researchers

  • Principal investigator: Chen, Albert — Scintillon Institute for Photobiology
  • Study coordinator: Chen, Albert

Related research

Other NIH-funded projects on the same topics.

  • Neuro-immune-blood vessel interactions in HIV brain disease model

    A new preclinical model will mimic how HIV enters and affects the brain, helping scientists study brain injury and cognitive problems in people living with HIV.

    NIH research Scintillon Institute for Photobiology · San Diego, United States · NIH-11391412

  • Augmenting Notch signaling to treat Alagille syndrome

    A study tests a small molecule that boosts Notch signaling to help people with Alagille syndrome by correcting liver and other organ defects.

    NIH research Scintillon Institute for Photobiology · San Diego, United States · NIH-11390997

  • Targeting tissue-specific cell energy balance to understand aging

    This project uses new genetic tools to change key energy-related molecules inside cells in specific tissues to help find ways to protect people from aging-related diseases like cancer and heart disease.

    NIH research Scintillon Institute for Photobiology · San Diego, United States · NIH-11357281

  • Tools to control redox balance in cancer cells to reveal metabolic vulnerabilities

    A cancer-focused research project is developing tissue- and organelle-specific tools to alter redox balance in cancer cells, helping doctors and patients understand how metabolism supports cancer growth.

    NIH research Scintillon Institute for Photobiology · San Diego, United States · NIH-11354493

  • Brain circuit that helps control hunger and food reward

    This research looks at whether specific brain pathways between the cerebellum and striatum change dopamine signals to reduce overeating, which could help people with appetite or weight problems.

    NIH research Scintillon Institute for Photobiology · San Diego, United States · NIH-11331265

  • Tools to control redox chemistry inside living cells for cancer and other diseases

    A NIH grant is funding development of new genetic tools to tune cellular redox balance, which could help understand and treat cancers and related conditions.

    NIH research Scintillon Institute for Photobiology · San Diego, United States · NIH-11260993

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.