Understanding how brain circuits control drug-seeking and avoidance behaviors
Control of opioid-motivated approach and avoidance behavior by neuronal ensembles in the basolateral amygdala and their projection targets in the nucleus accumbens
['FUNDING_CAREER'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-10898874
This study is looking at how certain brain circuits affect the cravings for and avoidance of opioids, which could help develop new treatments for people struggling with Opioid Use Disorder.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10898874 on ClinicalTrials.gov |
What this research studies
This research investigates the brain mechanisms involved in Opioid Use Disorder (OUD), focusing on how specific neuronal circuits in the basolateral amygdala influence both the desire to seek opioids and the ability to avoid them. By examining the distinct groups of neurons activated by rewarding and aversive opioid experiences, the study aims to uncover how these circuits can lead to compulsive drug-seeking behavior or avoidance responses. Patients may benefit from insights that could lead to new treatment strategies for OUD based on these neural pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Opioid Use Disorder who are seeking treatment options.
Not a fit: Patients who do not have Opioid Use Disorder or are not experiencing issues related to opioid use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that help individuals with Opioid Use Disorder manage their cravings and avoid relapse.
How similar studies have performed: Previous research has shown promising results in understanding the neural circuits involved in addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NEDELESCU, HERMINA — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: NEDELESCU, HERMINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.