Understanding how brain circuits change during learning
Unraveling the synaptic and circuit mechanisms underlying a plasticity-driving instructive signal
['FUNDING_OTHER'] · BRANDEIS UNIVERSITY · NIH-10686592
This study looks at how our brains learn and remember things by seeing how experiences change the connections between brain cells, and it could help people with memory issues, like those with Alzheimer's, by finding ways to improve how we learn and remember.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRANDEIS UNIVERSITY (nih funded) |
| Locations | 1 site (WALTHAM, UNITED STATES) |
| Trial ID | NIH-10686592 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms in the brain that allow for learning and memory by focusing on how neural connections change in response to experiences. It explores a novel learning rule called behavioral timescale synaptic plasticity (BTSP), which suggests that a single experience can lead to significant changes in brain activity. By studying these processes, the research aims to uncover how memories are formed and modified over time, which could have implications for understanding conditions like Alzheimer's disease. Patients may benefit from insights gained into how learning and memory functions can be preserved or enhanced.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing early symptoms of Alzheimer's disease or related dementias.
Not a fit: Patients with advanced Alzheimer's disease or those with other forms of dementia unrelated to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving memory and cognitive function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in understanding synaptic plasticity and its role in learning, suggesting that this approach could yield valuable insights.
Where this research is happening
WALTHAM, UNITED STATES
- BRANDEIS UNIVERSITY — WALTHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRIENBERGER, CHRISTINE — BRANDEIS UNIVERSITY
- Study coordinator: GRIENBERGER, CHRISTINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease