Understanding how brain circuits can improve thinking abilities
Improving cognition by understanding and harnessing the plasticity of gamma-generating circuits in prefrontal cortex
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10874749
This study is looking at how certain brain waves in the prefrontal cortex affect thinking and memory, with the hope of finding new ways to help people with cognitive challenges, especially those with schizophrenia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10874749 on ClinicalTrials.gov |
What this research studies
This research investigates the role of gamma-frequency synchronization in the prefrontal cortex, which is crucial for cognitive tasks. By using advanced techniques like optogenetics and calcium imaging, the study aims to identify how changes in this synchronization can either enhance or impair cognitive functions. The goal is to understand the underlying mechanisms that could lead to new treatments for cognitive deficits, particularly in conditions like schizophrenia. Patients may benefit from insights that could lead to targeted therapies for improving cognition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing cognitive deficits, particularly those related to schizophrenia.
Not a fit: Patients with cognitive functions that are not affected by gamma synchrony or those with conditions unrelated to cognitive deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance cognitive function in patients with cognitive deficits.
How similar studies have performed: Previous studies have shown promising results in manipulating gamma synchrony to improve cognitive functions, suggesting that this approach has potential for success.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SOHAL, VIKAAS SINGH — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: SOHAL, VIKAAS SINGH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.