Understanding how brain circuits are disrupted in Alzheimer's disease
Circuit mechanisms underlying network disruption and temporal processing deficits in Alzheimer's
This study is looking at how changes in the brain related to Alzheimer's disease affect hearing and behavior, using mice to understand when these issues start and how they impact the way we process sounds.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project ID | NIH-11078789 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which amyloid pathology affects neural circuits in the brain, leading to behavioral deficits in Alzheimer's disease. It focuses on two early biomarkers: difficulties in detecting auditory gaps and the disconnection of cortical networks. Using a mouse model of Alzheimer's, the study aims to identify when and how these disruptions occur and their impact on auditory processing. The research employs advanced techniques to analyze the functioning of neural circuits and their role in cognitive deficits associated with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease or those exhibiting early signs of cognitive impairment.
Not a fit: Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and early detection of Alzheimer's disease, potentially guiding future therapeutic strategies.
How similar studies have performed: Other research has shown promising results in understanding neural circuit disruptions in Alzheimer's, indicating that this approach has potential for significant insights.
Where this research is happening
Eugene, United States
- University of Oregon — Eugene, United States (Active)
Researchers
- Principal investigator: Wehr, Michael — University of Oregon
- Study coordinator: Wehr, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.