Understanding how brain circuits are affected in Alzheimer's disease
Neural circuit mechanisms underlying AD-related memory impairments
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10875780
This study is looking at how Alzheimer's disease affects brain connections that are important for memory, using mice to help us understand what happens in the brain as the disease gets worse, which could lead to new ways to help people with memory problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10875780 on ClinicalTrials.gov |
What this research studies
This research investigates the neural circuit mechanisms that contribute to memory impairments associated with Alzheimer's disease (AD). By using mouse models that mimic human AD, the study aims to explore how neurodegeneration alters the connections and activities of neurons in the hippocampus, a critical area for memory. The researchers will analyze the changes in circuit connections over time as the disease progresses, which could reveal important insights for developing new treatment strategies. Patients may benefit from this research as it seeks to uncover the underlying causes of memory decline in AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing memory impairments or are at risk for Alzheimer's disease.
Not a fit: Patients who are younger than 65 or do not have any cognitive decline or risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve memory function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown success in understanding neural circuits in other neurodegenerative diseases, suggesting that this approach may yield valuable insights for Alzheimer's disease as well.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XU, XIANGMIN — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: XU, XIANGMIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.