Understanding how brain circuits affect seizures in Angelman syndrome
Neural Circuit Mechanisms of Seizure Susceptibility in a Mouse Model of Angelman Syndrome
This study is looking at how seizures happen in mice with Angelman syndrome, a condition that affects brain development, to find new ways to help people with this syndrome who often struggle with seizures.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11025893 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind seizure susceptibility in a mouse model of Angelman syndrome, a severe neurodevelopmental disorder. The study focuses on understanding the brain circuitry that leads to seizures, which are common in individuals with this condition. By examining changes in neural pathways, particularly in the hippocampus, the researchers aim to identify potential targets for new anti-epileptic therapies. This work is crucial as over 90% of individuals with Angelman syndrome experience seizures, and current treatments are often ineffective.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Angelman syndrome, particularly those experiencing seizures.
Not a fit: Patients without Angelman syndrome or those who do not experience seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for seizures in patients with Angelman syndrome.
How similar studies have performed: Previous research has shown promise in understanding seizure mechanisms in other neurodevelopmental disorders, suggesting potential for success in this novel approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Ringelberg, Nicholas W — Univ of North Carolina Chapel Hill
- Study coordinator: Ringelberg, Nicholas W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.