Understanding how brain circuits affect our ability to adapt our thinking and behavior.
INVESTIGATING THE ROLE OF HIPPOCAMPUS - ORBITOFRONTAL CIRCUITS FOR COGNITIVE FLEXIBILITY
['FUNDING_R01'] · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · NIH-11007250
This study is looking at how certain parts of the brain help us adapt our thinking and behavior when faced with new challenges, especially for people dealing with stress-related mental health issues, to find new ways to improve their ability to cope and think flexibly.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11007250 on ClinicalTrials.gov |
What this research studies
This research investigates the neural circuits involved in cognitive flexibility, which is the ability to adjust thinking and behavior in response to new situations. It focuses on the connections between the ventral hippocampus and the orbitofrontal cortex, aiming to understand how these areas of the brain contribute to our ability to adapt and cope with stress. By studying these brain circuits, the research seeks to identify potential new treatments for cognitive impairments associated with psychiatric disorders, particularly those that arise from chronic stress. Patients may benefit from insights that could lead to innovative therapeutic approaches for improving cognitive flexibility.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing cognitive impairments related to chronic stress or psychiatric disorders.
Not a fit: Patients who do not have cognitive flexibility deficits or those without psychiatric conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cognitive flexibility, helping patients better manage stress and reduce the risk of psychiatric disorders.
How similar studies have performed: Previous research has shown promise in understanding brain circuits related to cognitive flexibility, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANACKER, CHRISTOPH — NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
- Study coordinator: ANACKER, CHRISTOPH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.