Understanding how brain circuits affect binge-eating disorder symptoms
Official title: The Computational Role of Corticostriatal Circuits in Binge-Eating Disorder Symptoms and Severity
Funded at Icahn School of Medicine at Mount Sinai · NIH-10747430 · Data updated 2026-11-12
This study is looking at how the brain works in people with binge-eating disorder to better understand why they make certain eating choices, with the hope of finding new ways to help them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $211,250 |
| NIH project number | 5R21MH129898-02 |
| Project ID | NIH-10747430 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who experience symptoms of binge-eating disorder.
✕Less likely to help
Patients who do not have binge-eating disorder or related eating disorders may not benefit from this research.
What this research studies
This research investigates the brain mechanisms that contribute to binge-eating disorder (BED), a condition affecting many individuals in the U.S. The study aims to identify how changes in brain circuits influence decision-making related to eating behaviors. By combining computational modeling with advanced brain imaging techniques, researchers will explore the relationship between neural connectivity and the severity of binge-eating symptoms. This approach seeks to uncover new targets for treatment by understanding the underlying neurobiological factors of BED.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for individuals suffering from binge-eating disorder.
How similar studies have gone: Previous research has shown promise in understanding brain mechanisms related to eating disorders, but this specific neurocomputational approach is relatively novel.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Berner, Laura a. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Berner, Laura a.
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.