Understanding how brain chemicals affect pain management
Midbrain cholinergic modulation of pain states
This study is looking at how a brain chemical called acetylcholine affects pain signals, with the goal of finding new, safer ways to manage chronic pain without using opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11092197 on NIH RePORTER |
What this research studies
This research investigates the role of acetylcholine, a brain chemical, in modulating pain signals in the body. By examining how acetylcholine release changes in response to pain and other stimuli, the study aims to uncover new mechanisms of pain control. The researchers will use advanced techniques, including a fluorescent sensor and brain slice electrophysiology, to explore these dynamics and identify potential non-opioid therapies for chronic pain. This work is particularly important given the current opioid crisis and the need for safer pain management options.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who suffer from chronic pain conditions.
Not a fit: Patients with acute pain or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, non-opioid treatments for chronic pain, reducing reliance on opioids and their associated risks.
How similar studies have performed: Previous research has shown promise in understanding pain modulation through neuromodulators, but this specific approach to acetylcholine dynamics in chronic pain is relatively novel.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Mcgehee, Daniel S — University of Chicago
- Study coordinator: Mcgehee, Daniel S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.