Understanding how brain changes in obesity lead to high blood pressure
Brainstem glial senescence and dysfunction in obesity-induced hypertension
['FUNDING_R01'] · OKLAHOMA STATE UNIVERSITY STILLWATER · NIH-11167557
This study is looking at how certain brain cells might play a role in high blood pressure caused by obesity, and it hopes to find new ways to help manage blood pressure for people dealing with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OKLAHOMA STATE UNIVERSITY STILLWATER (nih funded) |
| Locations | 1 site (STILLWATER, UNITED STATES) |
| Trial ID | NIH-11167557 on ClinicalTrials.gov |
What this research studies
This research investigates the role of brain cells, specifically astrocytes and microglia, in the development of high blood pressure associated with obesity. The study focuses on how oxidative stress affects these cells in a brain region that controls sympathetic nerve activity, which is linked to cardiovascular health. By examining the changes in these non-neuronal cells, the research aims to uncover new mechanisms that contribute to obesity-induced hypertension. Patients may benefit from insights that could lead to new treatments targeting these brain cells to manage blood pressure more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese and experiencing hypertension.
Not a fit: Patients who are not obese or do not have hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing hypertension in obese patients.
How similar studies have performed: While the specific focus on astrocytes and microglia in this context is novel, previous research has shown that targeting brain mechanisms can effectively influence blood pressure regulation.
Where this research is happening
STILLWATER, UNITED STATES
- OKLAHOMA STATE UNIVERSITY STILLWATER — STILLWATER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUBRAMANIAN, MADHAN — OKLAHOMA STATE UNIVERSITY STILLWATER
- Study coordinator: SUBRAMANIAN, MADHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.