Understanding how brain cells that support blood vessels change in Alzheimer's disease
Pericyte structural plasticity and cerebrovascular health
['FUNDING_R01'] · SEATTLE CHILDREN'S HOSPITAL · NIH-10788367
This study is looking at special cells in the brain that help keep blood vessels healthy, especially in people with Alzheimer's, to see how they react when things go wrong and how they can fix themselves, which could lead to new ways to help protect brain function in those living with the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10788367 on ClinicalTrials.gov |
What this research studies
This research investigates the role of pericytes, specialized cells that support blood vessels in the brain, particularly in the context of Alzheimer's disease. It aims to understand how these cells respond to loss and how they can repair themselves to maintain healthy blood flow and protect the blood-brain barrier. Using advanced imaging techniques, researchers will observe these processes in real-time within living brains, providing insights into how cerebrovascular health is affected in neurodegenerative diseases. The findings could lead to new strategies for preserving brain function in patients with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that improve blood flow and protect brain health in individuals with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding pericyte behavior in other contexts, but this specific approach to studying their role in Alzheimer's disease is relatively novel.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHIH, ANDY Y — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: SHIH, ANDY Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome