Understanding how brain cells that produce myelin are formed during development
Temporal and Spatial Control of Oligodendrocyte Fate Specification
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11098643
This study is looking at how certain brain cells, called oligodendrocytes, grow and develop from their early forms in zebrafish and mice, which could help us understand brain development better and find new ways to treat brain-related conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11098643 on ClinicalTrials.gov |
What this research studies
This research investigates the formation of oligodendrocytes, which are essential cells in the brain that create myelin, a protective sheath around nerve fibers. The study focuses on how these cells develop from neural progenitors in the spinal cord and forebrain, using advanced techniques like live imaging and single-cell RNA sequencing. By examining zebrafish and mice, the researchers aim to uncover the molecular mechanisms that dictate the fate of these progenitor cells, which could lead to new insights into brain development and potential treatments for neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that involve myelin damage or those interested in the underlying mechanisms of brain development.
Not a fit: Patients with conditions unrelated to oligodendrocyte function or myelin production may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain cell development and lead to innovative therapies for conditions related to myelin damage, such as multiple sclerosis.
How similar studies have performed: Previous research has shown success in understanding cell fate specification in other contexts, but this specific approach to oligodendrocyte development is relatively novel.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRANCO, SANTOS JOE — UNIVERSITY OF COLORADO DENVER
- Study coordinator: FRANCO, SANTOS JOE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.