Understanding how brain cells support long nerve fibers in Alzheimer's disease
Elucidating the Trophic Support of Long Axons by Metabolic Signaling in Oligodendrocytes
This study is looking at how certain brain cells help keep important nerve fibers healthy, especially in people with Alzheimer's, to find ways to protect these fibers from damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10898778 on NIH RePORTER |
What this research studies
This research investigates the role of oligodendrocytes, a type of brain cell, in maintaining the health of long axons, which are critical for proper neural function. The study focuses on how metabolic signaling within these cells affects their ability to support axons, particularly in the context of neurodegenerative diseases like Alzheimer's. By exploring the LKB1 signaling pathway, the research aims to uncover mechanisms that could prevent axonal degeneration, which is a key feature of Alzheimer's disease. Patients may benefit from insights gained into how to protect nerve fibers from damage associated with this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with Alzheimer's disease or related neurodegenerative conditions.
Not a fit: Patients with neurodegenerative diseases other than Alzheimer's or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving nerve function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of glial cells in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Beirowski, Bogdan — Ohio State University
- Study coordinator: Beirowski, Bogdan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.