Understanding how brain cells support long nerve fibers in Alzheimer's disease
Official title: Elucidating the Trophic Support of Long Axons by Metabolic Signaling in Oligodendrocytes
Funded at Ohio State University · NIH-10898778 · Data updated 2026-11-12
This study is looking at how certain brain cells help keep important nerve fibers healthy, especially in people with Alzheimer's, to find ways to protect these fibers from damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | February 9, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $358,381 |
| NIH project number | 5R01NS111024-05 |
| Project ID | NIH-10898778 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are diagnosed with Alzheimer's disease or related neurodegenerative conditions.
✕Less likely to help
Patients with neurodegenerative diseases other than Alzheimer's or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of oligodendrocytes, a type of brain cell, in maintaining the health of long axons, which are critical for proper neural function. The study focuses on how metabolic signaling within these cells affects their ability to support axons, particularly in the context of neurodegenerative diseases like Alzheimer's. By exploring the LKB1 signaling pathway, the research aims to uncover mechanisms that could prevent axonal degeneration, which is a key feature of Alzheimer's disease. Patients may benefit from insights gained into how to protect nerve fibers from damage associated with this condition.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving nerve function in patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of glial cells in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Beirowski, Bogdan — Ohio State University
- Study coordinator: Beirowski, Bogdan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.