Understanding how brain cells process information through dendrites
Elucidating mechanisms of active dendritic integration in vivo
This study is exploring how tiny branches on brain cells, called dendrites, help process information from our senses, using special tools to see how they work in real animals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Barbara NIH-funded |
| Lab location | 1 site (Santa Barbara, United States) |
| Project ID | NIH-11078348 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which neuronal dendrites process information in the brain. Using advanced techniques like electrophysiology, two-photon imaging, and optogenetics, the study aims to uncover how dendrites contribute to the integration of electrical signals during sensory processing in living animals. By examining the relationship between dendritic activity and neuronal output, the research seeks to clarify the role of dendrites in shaping how the brain interprets sensory information.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with early-stage Alzheimer's disease or related dementias who may benefit from advancements in understanding brain function.
Not a fit: Patients with advanced Alzheimer's disease or those with other unrelated neurological conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the cellular mechanisms underlying cognitive functions, potentially informing treatments for Alzheimer's disease and other neurodegenerative conditions.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown promise in understanding neuronal function and could pave the way for breakthroughs in treating cognitive disorders.
Where this research is happening
Santa Barbara, United States
- University of California Santa Barbara — Santa Barbara, United States (Active)
Researchers
- Principal investigator: Smith, Ikuko — University of California Santa Barbara
- Study coordinator: Smith, Ikuko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.