Understanding how brain cells manage dopamine for conditions like ADHD
Regulation of Dopamine Transporter by Trafficking
This work explores how brain cells control dopamine levels, which is important for understanding conditions like Attention Deficit Hyperactivity Disorder (ADHD) and the effects of certain medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11127595 on NIH RePORTER |
What this research studies
Our brain cells use a special protein called the dopamine transporter (DAT) to recycle dopamine, a chemical messenger, after it has sent its signal. This recycling process helps keep dopamine levels balanced in the brain, which is crucial for attention and focus. When DAT doesn't work correctly, it can contribute to conditions like ADHD or affect how drugs like amphetamines work. This research aims to uncover the exact ways DAT moves around inside brain cells and how its activity is regulated, including how certain substances might change its function. By understanding these fundamental processes, we hope to learn more about brain health and disease.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals with conditions like ADHD by advancing scientific knowledge.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not receive direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this research could lead to a deeper understanding of ADHD and how psychostimulants affect the brain, potentially guiding the development of new or improved treatments.
How similar studies have performed: This program has previously identified key mechanisms and kinetics of dopamine transporter movement within the brain, building on prior successes in this area.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Sorkin, Alexander D — University of Pittsburgh at Pittsburgh
- Study coordinator: Sorkin, Alexander D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.