Understanding how brain cells make decisions and influence behavior
Molecular recording to predict cell fate decisions and animal behavior
This study is looking at how brain cells grow and work together by using a special technique that lets scientists see what happens in these cells without harming them, which could help us understand learning and brain disorders better, and it's being done with mice to learn more about these important processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10260139 on NIH RePORTER |
What this research studies
This research investigates the complex processes of brain development and function by using a novel technology called single-cell 'Calling Cards'. This method allows researchers to capture and record molecular events in brain cells without destroying them, enabling a better understanding of how these cells influence behavior over time. By analyzing these recorded events, the research aims to correlate past molecular states with future cell fates and behaviors, providing insights into learning and neurological disorders. The study focuses on mice as a model organism to explore these fundamental questions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with neurological disorders or those interested in the mechanisms of learning and behavior.
Not a fit: Patients with conditions unrelated to neurological function or those not residing in the study's geographic area may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding brain function and the development of new treatments for neurological disorders.
How similar studies have performed: While the approach of using single-cell genomics has been explored, the specific method of using 'Calling Cards' for recording molecular events is a novel and untested strategy.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Mitra, Robi D — Washington University
- Study coordinator: Mitra, Robi D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.