Understanding how brain cells maintain their identity and function
A Mass Spectrometry Approach to the Genetic and Epigenetic Mechanisms Controlling Neuronal Identity
This study is looking at how a special protein called RP58 helps keep brain cells healthy and working properly, which could help us understand serious brain conditions like microcephaly and schizophrenia, and it involves examining brain cells from mice to see how RP58 does its job.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10802291 on NIH RePORTER |
What this research studies
This research investigates the genetic and epigenetic mechanisms that control the identity of neurons in the brain, focusing on a specific transcription factor called RP58. By using advanced techniques like mass spectrometry, the study aims to uncover how RP58 helps maintain neuronal identity and prevent the expression of genes from other cell types. This understanding could provide insights into serious neurological disorders such as microcephaly and schizophrenia, which are linked to defects in these processes. The research involves analyzing brain cells from mice to identify the interactions and functions of RP58 in both developing and adult brains.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who may be affected by neurological disorders linked to neuronal identity issues.
Not a fit: Patients with neurological disorders not related to neuronal identity or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurological disorders by enhancing our understanding of neuronal identity maintenance.
How similar studies have performed: Other research has shown promising results in understanding neuronal identity and its implications for brain disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Dahmane, Nadia — Weill Medical Coll of Cornell Univ
- Study coordinator: Dahmane, Nadia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.