Understanding how brain cells keep their balance
New approaches to determine the function of neuronal epigenetic marks
This project explores how brain cells use special chemical tags on their DNA to stay stable and function correctly, which could help us understand conditions like autism.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11077362 on NIH RePORTER |
What this research studies
Our brains are incredibly complex, with many different types of cells called neurons that need to work together perfectly. This project looks at how these neurons use tiny chemical changes on their DNA, called epigenetic marks, to adapt and maintain their unique roles. We are particularly interested in how a protein called MeCP2 helps manage these marks, as problems with MeCP2 are linked to certain neurological conditions. By understanding these fundamental processes, we hope to uncover new insights into how brain circuits develop and function, and what goes wrong in disorders like autism.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals affected by neurological disorders, including autistic disorder, in the long term.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not find direct benefit from participating in this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal new biological pathways that contribute to neurological disorders, potentially leading to new targets for future treatments.
How similar studies have performed: This project builds upon existing evidence from other researchers and the team's own recent findings regarding DNA methylation and MeCP2 in brain development.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Edwards, John R. — Washington University
- Study coordinator: Edwards, John R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.