Understanding how brain cells interact in Alzheimer's disease
Dissecting neuron-microglia-astrocyte interaction in AD pathogenesis
This study looks at how brain cells interact as we age and how these changes might play a role in Alzheimer's disease, hoping to find new ways to help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10875732 on NIH RePORTER |
What this research studies
This research investigates the interactions between neurons, microglia, and astrocytes in the brain, specifically focusing on how these interactions change with age and contribute to Alzheimer's disease. By using advanced technologies to analyze protein dynamics and gene expression in brain tissue from mouse models and human samples, the study aims to uncover the molecular mechanisms involved in the disease. Patients may benefit from insights gained about the cellular processes that lead to Alzheimer's, potentially guiding future therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk for developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for Alzheimer's disease, improving treatment options for patients.
How similar studies have performed: Other research has shown promise in understanding cellular interactions in Alzheimer's, but this approach using specific proteomic profiling is relatively novel.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Peng, Junmin — St. Jude Children's Research Hospital
- Study coordinator: Peng, Junmin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.