Understanding how brain cells influence cocaine addiction
Investigation of the Molecular Mechanisms Underlying Astrocytic CREB's Regulation of Cocaine Drug-Seeking
This study is looking at how certain brain cells called astrocytes behave when someone uses cocaine, hoping to find new ways to help people struggling with addiction.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11032351 on NIH RePORTER |
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in cocaine addiction. By examining how these cells respond to cocaine at the molecular level, the study aims to uncover the mechanisms that contribute to drug-seeking behavior. The approach involves manipulating astrocyte function and observing changes in behavior in animal models. This could lead to new insights into addiction and potential therapeutic targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with cocaine addiction or those at risk of developing substance use disorders.
Not a fit: Patients who are not affected by cocaine addiction or who have other unrelated substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cocaine addiction and improving recovery outcomes for patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of astrocytes in addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Holt, Leanne — Icahn School of Medicine at Mount Sinai
- Study coordinator: Holt, Leanne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.