Understanding how brain cells in the prefrontal cortex help with decision-making.
Neural Circuit Dynamics Underlying Perceptual Decision Making in the Macaque Dorsolateral Prefrontal Cortex
['FUNDING_FELLOWSHIP'] · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · NIH-10992113
This study looks at how different brain cells in a specific area of the brain help macaque monkeys make decisions based on what they see, using special techniques to understand how these cells work during tasks.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10992113 on ClinicalTrials.gov |
What this research studies
This research investigates the role of different types of brain cells in the dorsolateral prefrontal cortex (DLPFC) of macaque monkeys during decision-making tasks. By using advanced neurophysiology techniques and computational modeling, the study aims to determine how these cells contribute to making choices based on sensory information. The researchers will analyze the activity of these cells while the monkeys perform specific tasks, helping to uncover the underlying mechanisms of decision-making in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with decision-making impairments or related neurological conditions.
Not a fit: Patients without any decision-making disorders or brain injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of decision-making disorders, such as schizophrenia.
How similar studies have performed: Other research has shown success in understanding brain function related to decision-making, but this specific approach is novel.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, ERIC KENJI — BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
- Study coordinator: LEE, ERIC KENJI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury