Understanding how brain cells help protect against Alzheimer's disease
Role of microglia in cognitive resilience to AD
['FUNDING_R21'] · UNIVERSITY OF TEXAS MED BR GALVESTON · NIH-10831520
This study is looking at how certain brain cells might help some people stay mentally sharp even when they have signs of Alzheimer's, focusing on a protein called TREM2 that could help the brain clean up damaged connections; the goal is to find new ways to support brain health for those at risk of Alzheimer's.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS MED BR GALVESTON (nih funded) |
| Locations | 1 site (GALVESTON, UNITED STATES) |
| Trial ID | NIH-10831520 on ClinicalTrials.gov |
What this research studies
This research investigates the role of microglia, a type of brain cell, in helping some individuals remain cognitively healthy despite having the brain changes typically associated with Alzheimer's disease. The study aims to uncover the molecular and cellular mechanisms that contribute to this cognitive resilience, focusing on a specific protein called TREM2 that may enhance the brain's ability to clear damaged synapses. By analyzing brain samples from individuals who are cognitively intact but show signs of Alzheimer's pathology, the researchers hope to identify factors that could lead to new treatments for Alzheimer's disease. This work could pave the way for innovative therapies aimed at boosting cognitive resilience in at-risk populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who show signs of Alzheimer's disease pathology but remain cognitively healthy.
Not a fit: Patients who are already experiencing significant cognitive decline due to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help protect cognitive function in individuals at risk for Alzheimer's disease.
How similar studies have performed: Other research has shown promising results in understanding cognitive resilience in the context of Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
GALVESTON, UNITED STATES
- UNIVERSITY OF TEXAS MED BR GALVESTON — GALVESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRACASSI, ANNA — UNIVERSITY OF TEXAS MED BR GALVESTON
- Study coordinator: FRACASSI, ANNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease