Understanding how brain cells help form memories over time in Alzheimer's patients
Behavioral and pharmacological manipulation of time cell activity in the human mesial temporal lobe
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10982458
This study is looking at special brain cells that help us remember things over time, and it's for people with epilepsy and Alzheimer's Disease to see if we can find ways to boost their memory by understanding how these cells work.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10982458 on ClinicalTrials.gov |
What this research studies
This research investigates the role of 'time cells' in the human brain, particularly in the mesial temporal lobe, which are believed to help encode temporal information necessary for forming memories. By studying patients with epilepsy, the researchers will analyze how these time cells operate and interact during memory tasks. The goal is to determine whether these cells can be manipulated behaviorally or pharmacologically to improve memory function in individuals with Alzheimer's Disease. This approach combines advanced neurophysiological techniques with cognitive assessments to explore new avenues for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's Disease or related dementias who are experiencing memory difficulties.
Not a fit: Patients with non-degenerative memory issues or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance memory function in patients with Alzheimer's Disease.
How similar studies have performed: Previous research has shown promise in understanding the role of time cells in memory, but this specific approach is relatively novel and untested in the context of Alzheimer's Disease.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEGA, BRADLEY C — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: LEGA, BRADLEY C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease