Understanding how brain cells form connections
Cell-intrinsic mechanisms of presynaptic assembly
This study is looking at how brain cells connect with each other by focusing on special proteins that help build these connections, and it's designed for anyone interested in understanding how our brains work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10991764 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which brain cells, specifically presynaptic neurons, assemble and organize their connections. It focuses on a group of proteins known as synaptic cell-adhesion molecules (sCAMs) that are crucial for synapse development. By studying the interactions and transport of these proteins within the cells, the research aims to uncover how they contribute to the formation of synapses, which are essential for proper brain function. The study utilizes biological models, including the nematode C. elegans, to explore these cellular processes in detail.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those with genetic mutations related to synaptic cell-adhesion molecules.
Not a fit: Patients without neurodevelopmental disorders or those not carrying relevant genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of neurodevelopmental disorders like autism and potentially inform therapeutic strategies.
How similar studies have performed: Other research has shown promising results in understanding synaptic mechanisms, but this specific focus on cell-intrinsic processes is relatively novel.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Kurshan, Peri T — Albert Einstein College of Medicine
- Study coordinator: Kurshan, Peri T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.