Understanding how brain cells form connections
Cell-intrinsic mechanisms of presynaptic assembly
This study is looking at how brain cells connect with each other, focusing on special proteins that help build these connections, which is important for understanding conditions like autism and schizophrenia, and it uses tiny worms to learn more about these processes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10898545 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which brain cells, specifically presynaptic neurons, assemble and organize their connections. It focuses on a group of proteins known as synaptic cell-adhesion molecules (sCAMs) that play a crucial role in synapse development. By studying the interactions and transport of these proteins within the cells, the research aims to uncover new insights into how synapses are formed and maintained, which is particularly relevant for conditions like autism and schizophrenia. The approach involves using biological models, including the nematode C. elegans, to explore these cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or related neurodevelopmental conditions.
Not a fit: Patients with neurodevelopmental disorders not associated with synaptic cell-adhesion molecule dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodevelopmental disorders such as autism and schizophrenia.
How similar studies have performed: Previous research has shown that understanding synaptic mechanisms can lead to significant advancements in treating neurodevelopmental disorders, indicating that this approach has potential for success.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Kurshan, Peri T — Albert Einstein College of Medicine
- Study coordinator: Kurshan, Peri T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.