Understanding how brain cells divide and develop
Asymmetric Cell Division of Vertebrate Radial Glia Neural Progenitors
This study is looking at how certain brain cells divide and decide whether to keep making more of themselves or to become different types of brain cells, which is important for brain growth and healing, and it could help us understand brain disorders that happen when this process goes wrong.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11085252 on NIH RePORTER |
What this research studies
This research investigates the process of asymmetric cell division (ACD) in neural progenitor cells, which is essential for brain development and repair. By studying how these cells maintain their balance between self-renewal and differentiation, the research aims to uncover the molecular mechanisms that govern cell fate decisions. The team will utilize advanced techniques to analyze the role of specific proteins in establishing cell polarity during division, particularly in vertebrate models like zebrafish. Insights gained from this research could lead to a better understanding of brain disorders linked to cell division errors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with developmental or intellectual disabilities, as well as those affected by brain tumors or other brain disorders.
Not a fit: Patients with conditions unrelated to brain development or cell division may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating brain disorders and improving tissue repair mechanisms.
How similar studies have performed: Previous studies in invertebrate models have shown success in understanding cell division mechanisms, suggesting potential for similar breakthroughs in vertebrate systems.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Guo, Su — University of California, San Francisco
- Study coordinator: Guo, Su
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.