Understanding how brain cells develop to support flexible thinking
Sensitive periods for interneuron development supporting cognitive flexibility
This study is looking at how certain brain cells that help us think and adapt to new situations develop over time, especially in the part of the brain that controls our decision-making, to better understand how problems with these cells might lead to thinking difficulties in people with mental health conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11088733 on NIH RePORTER |
What this research studies
This research investigates the development of specific brain cells called interneurons that are crucial for cognitive flexibility, which is the ability to adapt thinking and behavior in response to changing situations. The study focuses on how these cells develop during different stages of growth, particularly in the prefrontal cortex, which is essential for executive functioning. By examining the role of certain types of interneurons and their activity, the research aims to uncover how disruptions in their development may lead to cognitive impairments seen in various neuropsychiatric disorders. This could provide insights into potential interventions for improving cognitive flexibility in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include adolescents and adults experiencing cognitive flexibility impairments due to conditions like ADHD, addiction, or Alzheimer's disease.
Not a fit: Patients with cognitive impairments not related to neuropsychiatric disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cognitive flexibility in individuals with neuropsychiatric disorders.
How similar studies have performed: While the specific focus on the development of PV and SST interneurons is novel, related research has shown that understanding brain circuitry can lead to significant advancements in treating cognitive impairments.
Where this research is happening
New York, United States
- New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC — New York, United States (Active)
Researchers
- Principal investigator: Canetta, Sarah E — New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
- Study coordinator: Canetta, Sarah E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.