Understanding how brain cells develop their unique identities
Chromatin factor regulation of neuroblast progenitor genome dynamics
This project explores how the organization of our genetic material inside early brain cells helps them become different types of neurons during brain development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11125916 on NIH RePORTER |
What this research studies
Our brains are incredibly complex, with many different types of cells, all starting from a few basic building blocks. This work looks at how the genetic information within these early brain cells is arranged in 3D space, which might guide them to become specific types of neurons. We want to understand how these early brain cells gain the ability to create different cell types and how this ability changes over time. By learning more about this fundamental process, we hope to uncover the secrets behind how our brains are built and function.
Who could benefit from this research
Good fit: This basic science work does not directly involve patient participation at this stage, but future applications could relate to individuals with neurodevelopmental conditions.
Not a fit: Patients seeking immediate treatment options or direct clinical interventions will not find direct benefit from this foundational biological investigation.
Why it matters
Potential benefit: This foundational knowledge could help us understand the origins of brain disorders and potentially lead to new ways to address developmental issues in the future.
How similar studies have performed: While the general principles of genome folding are known, how specific 3D organization directly impacts gene expression and cell function in brain development is still largely unexplored.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Kohwi, Minoree — Columbia University Health Sciences
- Study coordinator: Kohwi, Minoree
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.