Understanding how brain cells develop in the cerebellum
Regulatory mechanisms of cerebellar lineage development
['FUNDING_R01'] · VANDERBILT UNIVERSITY · NIH-11088845
This study looks at how certain brain cells that help with movement and thinking develop in babies, especially those born early, to understand what goes wrong when these cells don’t form properly, which could help find new treatments for brain development issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-11088845 on ClinicalTrials.gov |
What this research studies
This research investigates the development of granule cells in the cerebellum, which are crucial for motor control and cognitive functions. It focuses on the regulatory mechanisms that govern the lineage of these cells from precursors during early development. By studying specific transcription factors and their interactions, the research aims to uncover how disruptions in these processes can lead to conditions like cerebellar hypoplasia, particularly in premature infants. Patients may benefit from insights that could lead to new therapeutic strategies for developmental brain disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and children diagnosed with conditions related to cerebellar development, such as autism spectrum disorder or ataxia.
Not a fit: Patients with fully developed cerebellar function or those without any neurological developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new understanding and potential treatments for developmental brain disorders associated with cerebellar hypoplasia.
How similar studies have performed: Other research has shown success in understanding cell lineage development in the brain, suggesting that this approach may yield valuable insights.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHIANG, CHIN — VANDERBILT UNIVERSITY
- Study coordinator: CHIANG, CHIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder