Understanding how brain cells develop for motor control after injury or disease
Transcriptional Regulation Over Neurogenesis of Cortical Output Neuron Segmental Identity and Diversity
This study is looking at how certain brain cells that help control movement develop and connect in people with conditions like ALS and after strokes, with the goal of finding ways to improve recovery and movement for those who are paralyzed.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Winifred Masterson Burke Med Res Inst NIH-funded |
| Lab location | 1 site (White Plains, United States) |
| Project ID | NIH-11042784 on NIH RePORTER |
What this research studies
This research investigates the development of specific brain cells called subcerebral projection neurons, which are crucial for voluntary motor control. It focuses on how these neurons connect to other parts of the brain and spinal cord, particularly in conditions like amyotrophic lateral sclerosis (ALS) and after strokes. By examining the molecular mechanisms that guide the formation of these connections during development, the research aims to uncover ways to enhance recovery and motor function in patients with paralysis. The approach includes studying the differences in brain circuitry that affect recovery outcomes in various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with amyotrophic lateral sclerosis, stroke survivors, and patients with cerebral palsy.
Not a fit: Patients with conditions unrelated to motor neuron degeneration or those who do not experience motor control issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve motor function and recovery in patients with conditions like ALS, stroke, and cerebral palsy.
How similar studies have performed: Previous research has shown promise in understanding motor control circuits, but this specific investigation into the developmental mechanisms is relatively novel.
Where this research is happening
White Plains, United States
- Winifred Masterson Burke Med Res Inst — White Plains, United States (Active)
Researchers
- Principal investigator: Sahni, Vibhu Vinodchandra — Winifred Masterson Burke Med Res Inst
- Study coordinator: Sahni, Vibhu Vinodchandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.