Understanding how brain cells decide to become neurons
Abscission regulation of corticogenesis
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-10763794
This study is looking at how brain cells called neural stem cells change into neurons, focusing on an important step in that process, and it aims to help us understand brain development and related disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10763794 on ClinicalTrials.gov |
What this research studies
This research investigates the process by which neural stem cells (NSCs) in the brain transition from dividing to becoming neurons, focusing on a critical step called abscission. Researchers will use advanced techniques to analyze how the timing and regulation of abscission influence the fate of these cells during brain development. By studying both living organisms and cell cultures, the team aims to uncover the mechanisms that dictate whether NSCs continue to proliferate or differentiate into neurons. This could provide insights into developmental disorders and brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autism spectrum disorder (ASD) or those interested in the biological mechanisms of brain development.
Not a fit: Patients with fully developed brains or those not affected by neurodevelopmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating conditions like autism by enhancing our understanding of brain development.
How similar studies have performed: While the specific focus on abscission in NSCs is novel, related research has shown success in understanding cell fate decisions in other contexts.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DWYER, NOELLE D — UNIVERSITY OF VIRGINIA
- Study coordinator: DWYER, NOELLE D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder