Understanding how brain cells contribute to Huntington's disease
The Pathogenic Role of Interneurons in Huntington's Disease
['FUNDING_R01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11001184
This study is looking at how certain brain cells, called interneurons, might play a role in Huntington's disease, and it's using specially modified mice to learn more about how problems with these cells during brain development could lead to the disease, which could help find new ways to treat it for people affected by Huntington's.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11001184 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific brain cells called interneurons in the development of Huntington's disease, a serious neurodegenerative condition. By using genetically modified mouse models, the researchers aim to understand how changes in the production and function of these cells during brain development can lead to the disease. The study focuses on identifying the mechanisms that disrupt interneuron production and how this affects brain connectivity and stress responses. Patients may benefit from insights gained about the disease's progression and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Huntington's disease or those at risk due to family history.
Not a fit: Patients with other neurodegenerative disorders unrelated to Huntington's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for delaying the onset or progression of Huntington's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of brain cells in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOLERO, ALDRIN ENRIQUE — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: MOLERO, ALDRIN ENRIQUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.