Understanding how brain cells connect with support cells
Development of Specific Neuron-Glia Attachments
This study looks at how brain cells connect with each other during development, using tiny worms to learn more about the genes and processes involved, which could help us understand issues that lead to brain disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11002319 on NIH RePORTER |
What this research studies
This research investigates the specific connections between neurons and glial cells in the brain, focusing on how these attachments are formed during development. By studying a particular sensory neuron in the model organism C. elegans, researchers aim to uncover the genetic and developmental mechanisms that dictate these crucial interactions. The project utilizes advanced techniques to visualize and manipulate these connections in live animals, providing insights into how defects in these processes may contribute to neurodevelopmental disorders. Ultimately, this work seeks to enhance our understanding of brain wiring and cell adhesion.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by neurodevelopmental disorders, particularly those related to neuron-glia interactions.
Not a fit: Patients with conditions unrelated to neurodevelopmental disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into neurodevelopmental disorders and potential therapeutic strategies.
How similar studies have performed: While the specific focus on neuron-glia attachments in this context may be novel, previous research has shown success in understanding neuron interactions and their implications for brain function.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Heiman, Maxwell — Boston Children's Hospital
- Study coordinator: Heiman, Maxwell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.