Understanding how brain cells connect and communicate
Unraveling the developmental logic of cortical long-range projections using in situ sequencing-based neuroanatomy
This study is looking at how different brain cells communicate with each other and how their genes affect their connections, which could help us understand brain development and function better, especially for people with brain disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Allen Institute NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10472363 on NIH RePORTER |
What this research studies
This research investigates the complex connections between different types of neurons in the brain, focusing on how their gene expression patterns relate to their long-range projections. By using advanced techniques in single-cell transcriptomics, the study aims to map these connections more accurately than traditional methods allow. This could provide insights into how neurons are wired together during development and how this wiring influences brain function in adulthood. The findings may help clarify the relationship between gene expression and neuronal connectivity, which is crucial for understanding brain function and disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are interested in the biological underpinnings of brain function.
Not a fit: Patients with acute neurological conditions requiring immediate intervention may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of brain connectivity, potentially informing treatments for neurological disorders.
How similar studies have performed: Other research in the field of neuroanatomy and transcriptomics has shown promising results, indicating that this approach could yield significant insights.
Where this research is happening
Seattle, United States
- Allen Institute — Seattle, United States (Active)
Researchers
- Principal investigator: Chen, Xiaoyin — Allen Institute
- Study coordinator: Chen, Xiaoyin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.