Understanding how brain cells communicate with each other
Molecular and genetic decoding of neuron-glial interactions
This study is looking at how brain cells work together, especially the ones that help protect and support nerve cells, to better understand brain health and diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11062759 on NIH RePORTER |
What this research studies
This research investigates the interactions between neurons and glial cells in the brain, which are crucial for normal nervous system function. The project aims to develop advanced tools to profile the molecules involved in these interactions, particularly focusing on oligodendrocytes, the cells responsible for producing myelin. By utilizing techniques like CRISPR and single-cell RNA sequencing, the researchers will explore the molecular mechanisms that govern how these cells communicate and support each other during brain development and function. This work could lead to new insights into brain health and diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting the central nervous system, such as multiple sclerosis or other demyelinating diseases.
Not a fit: Patients with purely peripheral nervous system conditions or those without neurological issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain cell interactions, potentially leading to new treatments for neurological disorders.
How similar studies have performed: Other research has shown promise in understanding neuron-glial interactions, but this approach using advanced genetic tools is relatively novel.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Sun, Lu — Ut Southwestern Medical Center
- Study coordinator: Sun, Lu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.