Understanding how brain cells communicate to regulate motor behavior
The role of astrocyte-neuron signaling in closing a critical period required for motor circuit structure function and behavior
This study looks at how special brain cells called astrocytes work with nerve cells to help the brain develop properly, which is important for movement and behavior, and it hopes to find out how problems in this process might be linked to conditions like autism and epilepsy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10993586 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which astrocytes, a type of brain cell, interact with neurons to close critical periods of brain development. These critical periods are essential for the proper formation of neural circuits that control movement and behavior. By studying these interactions, the research aims to uncover how disruptions in this process may contribute to conditions like autism and epilepsy. The approach includes advanced techniques in molecular genetics and live imaging to analyze brain cell behavior in both animal models and human contexts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old who are diagnosed with autism spectrum disorder or related neurodevelopmental conditions.
Not a fit: Patients who are over 21 years old or do not have autism spectrum disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for improving motor function and behavior in individuals with autism and related disorders.
How similar studies have performed: Previous research has shown promising results in understanding critical periods in brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Ackerman, Sarah D — Washington University
- Study coordinator: Ackerman, Sarah D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.