Understanding how brain cells communicate in conditions like autism
The dual roles of GABA in excitatory synaptic plasticity
This project explores how different types of brain cell connections, called synapses, work together to maintain balance in the brain, which is important for conditions like autism.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11135331 on NIH RePORTER |
What this research studies
Our brains rely on a delicate balance between excitatory and inhibitory signals, like an orchestra needing both loud and soft notes to sound right. This balance is crucial for healthy brain function, and imbalances are seen in conditions such as autism. This work uses advanced imaging techniques to observe how inhibitory synapses, which quiet brain activity, influence excitatory synapses, which boost activity. We aim to discover the specific ways these connections talk to each other and how this communication changes as the brain develops.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation but aims to benefit individuals with neurological conditions, particularly those related to brain development and synaptic imbalance, such as autistic disorder.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not find direct benefit from participating in this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of brain development and function, potentially paving the way for new approaches to help individuals with conditions like autism.
How similar studies have performed: Previous studies have shown that inhibitory and excitatory synapses communicate, and our preliminary findings further support that inhibitory activity can affect excitatory connections.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Oh, Won Chan — University of Colorado Denver
- Study coordinator: Oh, Won Chan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.