Understanding how brain cells communicate during memory formation
Official title: cAMP signaling and three activity states of hippocampal neurons
Funded at University of New Hampshire · NIH-11044296 · Data updated 2026-11-12
This study looks at how certain brain cells in the hippocampus get ready and work together to help us remember things, which could lead to better treatments for memory-related issues like dementia and PTSD.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Hampshire NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 1, 2021 |
| Project end | November 10, 2027 |
| Funding year | 2025 |
| Award (this year) | $460,500 |
| NIH project number | 2R15MH125305-02 |
| Project ID | NIH-11044296 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing cognitive impairments, such as those with dementia, schizophrenia, or PTSD.
✕Less likely to help
Patients with cognitive function intact or those not experiencing memory-related disorders may not benefit from this research.
What this research studies
This research investigates the different activity states of neurons in the hippocampus, which is crucial for memory formation. It focuses on how certain neurons become 'primed' and then 'engaged' to help form and retrieve memories. By studying the signaling pathways involved, particularly the role of cAMP and NMDA receptors, the research aims to uncover the mechanisms behind learning and memory. This could lead to insights into cognitive disorders like dementia and PTSD, potentially improving treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for cognitive dysfunctions, enhancing memory and learning capabilities in affected patients.
How similar studies have gone: Previous research has shown promising results in understanding neuronal signaling related to memory, indicating that this approach has potential for success.
Where this research is happening
-
University of New Hampshire
Durham, United States Active
Researchers
- Principal investigator: Chen, Xuanmao — University of New Hampshire
- Study coordinator: Chen, Xuanmao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.