Understanding how brain cells communicate during memory formation
cAMP signaling and three activity states of hippocampal neurons
['FUNDING_R15'] · UNIVERSITY OF NEW HAMPSHIRE · NIH-11044296
This study looks at how certain brain cells in the hippocampus get ready and work together to help us remember things, which could lead to better treatments for memory-related issues like dementia and PTSD.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEW HAMPSHIRE (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11044296 on ClinicalTrials.gov |
What this research studies
This research investigates the different activity states of neurons in the hippocampus, which is crucial for memory formation. It focuses on how certain neurons become 'primed' and then 'engaged' to help form and retrieve memories. By studying the signaling pathways involved, particularly the role of cAMP and NMDA receptors, the research aims to uncover the mechanisms behind learning and memory. This could lead to insights into cognitive disorders like dementia and PTSD, potentially improving treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive impairments, such as those with dementia, schizophrenia, or PTSD.
Not a fit: Patients with cognitive function intact or those not experiencing memory-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for cognitive dysfunctions, enhancing memory and learning capabilities in affected patients.
How similar studies have performed: Previous research has shown promising results in understanding neuronal signaling related to memory, indicating that this approach has potential for success.
Where this research is happening
DURHAM, UNITED STATES
- UNIVERSITY OF NEW HAMPSHIRE — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, XUANMAO — UNIVERSITY OF NEW HAMPSHIRE
- Study coordinator: CHEN, XUANMAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.