Understanding how brain cells communicate during development
Role of proteoglycan-mediated trans-axonal signaling in pre-target topographic sorting
This study looks at how brain cells, especially the long parts called axons, find their way to the right spots in the brain during development, using zebrafish embryos to learn how certain proteins help guide them and get rid of any that go off course, which is important for keeping our brains working well.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10541897 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which brain cells, specifically axons, are organized into precise maps during development. It focuses on how certain proteins, called proteoglycans, influence the sorting of axons as they grow towards their targets in the brain. By studying zebrafish embryos, the research aims to uncover how misrouted axons are selectively eliminated to ensure proper brain function. This approach allows for a detailed examination of the molecular pathways involved in this critical process.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with developmental neurological conditions or those interested in the underlying mechanisms of brain function.
Not a fit: Patients with fully developed nervous systems and no neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into brain development and potential therapies for neurological disorders.
How similar studies have performed: Other research has shown success in understanding axon guidance and sorting, but this specific approach using zebrafish is relatively novel.
Where this research is happening
Columbia, United States
- University of South Carolina at Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Poulain, Fabienne Emmanuelle — University of South Carolina at Columbia
- Study coordinator: Poulain, Fabienne Emmanuelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.