Understanding how brain cells communicate at synapses
Official title: CRCNS US-German Research Proposal: Quantitative and Computational Dissection of Glutamatergic Crosstalk at Tripartite Synapses
Funded at University of South Florida · NIH-11016964 · Data updated 2026-11-12
This study is looking at how brain cells called neurons and astrocytes work together to share a chemical called glutamate, which helps send messages in the brain, and it aims to understand how this sharing affects brain function and flexibility.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $113,400 |
| NIH project number | 5R01NS130916-03 |
| Project ID | NIH-11016964 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting brain function, such as neurodegenerative diseases or psychiatric disorders.
✕Less likely to help
Patients with non-neurological conditions or those not experiencing cognitive or neurological symptoms may not benefit from this research.
What this research studies
This research investigates the complex interactions between neurons and astrocytes at synapses in the brain, focusing on how glutamate, a key neurotransmitter, is shared between synapses. By using advanced quantitative and computational techniques, the study aims to dissect the mechanisms of glutamate crosstalk, which can influence how signals are transmitted and processed in the brain. The research will explore how the structure and function of the surrounding cellular environment affect this communication, potentially leading to insights into brain plasticity and function.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain communication, potentially leading to new treatments for neurological disorders.
How similar studies have gone: Previous research has shown promising results in understanding synaptic communication, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Ullah, Ghanim — University of South Florida
- Study coordinator: Ullah, Ghanim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.