Understanding how brain cells choose specific genes for proper wiring
How genome architecture controls Protocadherin gene choice at single-allele resolution
This study is looking at how brain cells choose certain genes that help them connect properly, using special imaging to see the DNA structure in individual cells, and it’s aimed at understanding how these choices affect brain function, especially in the sense of smell.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11071771 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind how brain cells select specific Protocadherin genes, which are crucial for the proper wiring of the brain. By using advanced imaging techniques to visualize the 3D structure of DNA in individual cells, the study aims to uncover how these genes are regulated during development and maintained throughout a neuron’s life. The research focuses on neurons in the olfactory epithelium, aiming to link gene expression choices to the physical architecture of the genome. This could provide insights into the fundamental processes that govern brain connectivity and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autism spectrum disorder (ASD) or those interested in the genetic and developmental aspects of brain function.
Not a fit: Patients with conditions unrelated to brain wiring or genetic expression may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of brain wiring, potentially informing treatments for neurological conditions such as autism.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation through similar genomic architecture approaches, indicating a potential for success in this area.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Buckley, Alexander — University of California, San Francisco
- Study coordinator: Buckley, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.