Understanding how brain cells called astrocytes develop in the cerebellum
Regulation of astrocyte diversity in the cerebellum
['FUNDING_R01'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-11109663
This project looks at how different types of brain cells, called astrocytes, develop and function in the cerebellum, which is important for movement and balance.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-11109663 on ClinicalTrials.gov |
What this research studies
Our brains contain specialized cells called astrocytes that play many roles, and their specific functions can vary depending on where they are located. This project explores the tiny details of how these astrocytes become so diverse in the cerebellum, a brain area crucial for coordination. We are focusing on a specific factor, YY1, that appears to be key in guiding how these cells develop and maintain their unique roles. By understanding these basic processes, we hope to learn more about how the cerebellum works and what happens when things go wrong.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies building on this work might seek individuals with cerebellar conditions.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not benefit from this basic science project.
Why it matters
Potential benefit: If successful, this basic understanding of astrocyte development could eventually lead to new ways to address conditions affecting the cerebellum or brain development.
How similar studies have performed: While the general understanding of astrocyte diversity is growing, the specific molecular mechanisms controlling this diversity, especially involving YY1 in the cerebellum, are still largely unknown.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KORDULA, TOMASZ K — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: KORDULA, TOMASZ K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.