Understanding how brain cells called astrocytes develop and function
Molecular pathways regulating astrocyte morphogenesis and function
This study is exploring how certain brain cells called astrocytes work and change shape, which could help us understand brain conditions like autism and Alexander's disease, ultimately benefiting patients by revealing new insights into brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11088279 on NIH RePORTER |
What this research studies
This research investigates the development and function of astrocytes, which are crucial cells in the brain that support neuronal activity and maintain brain health. The study aims to uncover the molecular pathways that regulate the complex shape and interactions of astrocytes with other brain cells. By using genetic screening in model organisms, the researchers have identified specific genes that influence astrocyte morphology and function, which could have implications for neurological diseases like autism and Alexander's disease. Patients may benefit from insights gained about astrocyte function and its role in brain disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or Alexander's disease.
Not a fit: Patients with neurological conditions unrelated to astrocyte function may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurological conditions associated with astrocyte dysfunction.
How similar studies have performed: Other research has shown promising results in understanding astrocyte function and its implications for brain health, indicating that this approach has potential for significant findings.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Monk, Kelly R — Oregon Health & Science University
- Study coordinator: Monk, Kelly R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.