Understanding how brain cells behave differently in early Alzheimer's Disease
Mechanism and restoration of altered firing in interneurons during early phase Alzheimer's Disease
This study is looking at how certain brain cells change in people with early Alzheimer's Disease, hoping to find ways to fix these changes and eventually help develop new treatments to slow down the disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10894689 on NIH RePORTER |
What this research studies
This research investigates the changes in specific brain cells called fast-spiking parvalbumin interneurons during the early stages of Alzheimer's Disease. By using advanced imaging techniques, the study aims to understand how these cells' firing patterns are altered before the onset of amyloid-beta plaque accumulation. The goal is to identify the mechanisms behind these changes and explore potential ways to restore normal firing, which could help in developing early interventions for Alzheimer's. Patients may benefit from insights that could lead to new treatment strategies aimed at preventing or slowing the progression of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals in the early stages of Alzheimer's Disease or those at risk of developing it.
Not a fit: Patients with advanced Alzheimer's Disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that prevent or slow the onset of Alzheimer's Disease.
How similar studies have performed: Other research has shown promising results in understanding neuronal behavior in early Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Goettemoeller, Annie M — Emory University
- Study coordinator: Goettemoeller, Annie M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.