Understanding how brain cells affect the performance of implanted devices in the brain
Mechanisms of Oligodendrocyte Activity on Chronic Brain Implants and Recording Performance
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11093966
This study is looking at how certain brain cells react to long-term brain implants, which could help make devices that record brain activity work better and last longer for people with brain injuries.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11093966 on ClinicalTrials.gov |
What this research studies
This research investigates the role of oligodendrocytes, a type of brain cell, in the response to chronic brain implants and how this affects the performance of devices that record brain activity. By using advanced imaging techniques, the study aims to observe the changes in brain tissue around these implants over time. The goal is to improve the longevity and effectiveness of neuroprosthetic devices, which are used to help restore functions in patients with brain injuries. This research could lead to better brain-computer interfaces and improved treatments for neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic brain injuries or conditions requiring neuroprosthetic devices.
Not a fit: Patients without chronic brain injuries or those not requiring brain implants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the performance and durability of brain implants, leading to improved outcomes for patients with neurological disorders.
How similar studies have performed: Previous research has shown promise in understanding the role of other glial cells in chronic brain implants, but the specific focus on oligodendrocytes is relatively novel.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOZAI, TAKASHI DANIEL YOSHIDA — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: KOZAI, TAKASHI DANIEL YOSHIDA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury